Important IconIn terms of medical management of the symptoms associated with Chromosome15q 11.2-13.1 Duplication Syndrome, families should be aware that individuals with chromosome15 duplications may tolerate medications differently and may be more sensitive to side effects for some classes of medications, such as the serotonin re-uptake inhibitor type medications (SSRI). Thus, these should be used with caution and any new medication should be instituted in a controlled setting, with slow titration of levels and with a clear endpoint as to what the expected outcome for treatment is.

Reference: Schanen, C: Research update on chromosome 15 duplications – idic(15) and interstitial duplications: The duplication 15q syndrome. Presentation at 2005 International Conference on Isodicentric 15 and Related Disorders. Hogart A, Wu D, Lasalle JM, Schanen NC. The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13. Neurobiol Dis. 2009:in press. 

N. Carolyn Schanen, M.D., Ph.D.
Thibert RL, Conant KD, Braun EK, Bruno P, Said RR, Nespeca MP, Thiele EA. Epilepsy in Angelman syndrome: A questionnaire-based assessment of the natural history and current treatment options. Epilepsia. 2009;50(11):2369-2376.
Research of  Ronald Thibert DO MsPH
updated July 13, 2013